12/08/2020

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Silks and shells can repair human tissue – Information Centre – Research & Innovation

Under the EU-funded project REMIX, researchers from Europe and Asia have joined forces to flip all-natural textile and foods fibres, like silk and shells, into chopping-edge health care applications this sort of as prosthetics and human tissue repair service.


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Natural fibres from resources this sort of as silk and crab shells could be utilised in drugs to swap artificial resources like plastics to repair damaged human tissue.

Under the EU-funded project REMIX, tissue-engineering researchers from Europe and Asia are producing the by natural means derived materials’ one of a kind attributes for tissue repair service to help individuals conquer health problems, as effectively as for use in health care prosthetics and as carriers for medication.

‘We’re operating on the style and use of artificial matrixes derived from silk and other resources that can converse with the biological setting, assisting the procedure of therapeutic and regeneration of tissues damaged by sickness or trauma,’ suggests Professor Antonella Motta, researcher at the University of Trento, Italy, and REMIX project coordinator.

The project is focusing on reusing the silk that is a waste product or service in the textile sector as effectively as other waste resources like leftover cashmere animal hairs, polymers derived from crops and algae, and waste foods products from crustaceans and marine organisms, like jellyfish. This suggests they are economical, sustainable and all-natural, and healthy into the thought of a round economy by offering waste products a new life.

Cell regeneration with silk

Under the project, researchers from the University of Trento in Italy and the University of Chonbuk in South Korea have previously identified that silk, collagen and laminin – a protein discovered in human tissue – can be utilised to assemble a molecule that mimics a all-natural, additional-mobile matrix framework that can help with the regeneration of cells in the body’s central anxious process.

Meanwhile, researchers from Italy, Chulalongkorn University in Thailand and the Mongolian University of Science and Technological innovation have integrated sea buckthorn oil into alginate hydrogels to treat damaged skin.

Scientists from Thailand and the University of Minho, Portugal have labored collectively to produce a procedure that accelerates the gelation of a silk remedy employing phospholipids discovered in soya, rapeseed, sunflower, hen eggs, bovine milk and fish eggs. This materials could then be injected into wounds to fill in damaged locations, lowering the invasiveness of surgical treatments. REMIX has previously submitted two patents on two of the procedures its researchers have made.

Regeneration and regrowth

The project has also manufactured important developments in the field of all-natural prosthetics. Professional medical prosthetics are presently manufactured of plastics – like polyethylene, polypropylene, acrylics and polyurethane – as effectively as some all-natural resources. Earlier, resources this sort of as wooden, rubber and light-weight metals have been utilised.

The all-natural silk utilised in REMIX is manufactured by silkworms and silk spiders it has the positive aspects of currently being lighter on the setting and getting fewer impression on the human body. ‘Our prosthetics are intended to encourage complete therapeutic through the regeneration and regrowth of practical tissues,’ suggests Motta.

The project is also employing silk to build 3D in-vitro versions that can be utilised for testing medication and beauty products, staying away from animal testing. In addition, researchers are carrying out a major in-depth assessment of the use of silk, as effectively as exploring how the procedures they produce could be standardised and repeatable.

The moment the project final results are ready, REMIX will make them out there on an open platform for all researchers to use. They will then pick out the most promising final results and goal to operate with industrial companies to use these in professional products.
‘The vision is to set up a platform to velocity up the development of products on the market place at an cost-effective selling price,’ suggests Motta.

REMIX acquired funding from the Marie Skłodowska-Curie Actions programme.